Clicking Polymer Networks Together: Approaches to Form Smart, Functional Polymers from Click Chemistry
Christopher N. Bowman
A new paradigm encompassing several distinct chemical reactions and, more importantly, a generalized approach to molecular design and synthesis has been rapidly adopted in the fields of chemical synthesis, biotechnology, materials science, drug discovery, surface science, and polymer synthesis and modification. The Click Chemistry paradigm focuses on implementation of highly efficient reactions that achieve quantitative conversion under mild conditions. As such, these reactions represent ideal candidates for further development, understanding and implementation. In particular, the synergistic combination of these click chemistries with photochemical initiation and polymer formation has been used to afford 4D control of polymer formation, structure and patterned assembly. Here, we will focus on several vignettes related to our implementation of photoclickable polymer systems. The first of these focuses on the development of approaches to photoinitiate the Cu(I) catalyzed azide-alkyne cycloaddition (CuAAC) click reaction. Here, implementation of this reaction in surface modification, hydrogel formation, and lithography as well as in the development of a new class of photopolymerized polymer networks will be presented. Secondly, we will discuss the implementation of click chemistry in the development of sequence controlled polymer structures, particularly click-based oligonucleotides that represent a novel class of DNA mimics.
Professor Christopher N. Bowman received his B.S. and Ph.D. in Chemical Engineering from Purdue University in 1988 and 1991, respectively. After receiving his Ph.D., he began his academic career at the University of Colorado in January of 1992 as an Assistant Professor. Since that time Professor Bowman has built a program focused on the fundamentals and applications of crosslinked polymers formed via photopolymerization reactions. He works in the broad areas of the fundamentals of polymerization reaction engineering, polymer chemistry, crosslinked polymers, photopolymerizations and biomaterials. Professor Bowman has remained at Colorado throughout his academic career and is currently the Patten Endowed Chair of the Department of Chemical and Biological Engineering as well as a Clinical Professor of Restorative Dentistry at the University of Colorado at Denver.